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Similar content being viewed by others Introduction G protein-coupled receptors (GPCRs) and their immediate transducersheterotrimeric G proteinshave been the subject of intensive scrutiny for decades, primarily due to their pivotal roles in innumerable physiological and pathological processes 1

Co-immunoprecipitation and immunofluorescence assays demonstrated that HRD1 physically interacts with BMAL1 and enhances its K48-linked polyubiquitination, leading to proteasome-mediated degradation without altering BMAL1 mRNA levels (Mendoza-Viveros et al., 2017), and consistently, HRD1 overexpression significantly reduces PER1 and DBP mRNA levels, suggesting downstream transcriptional suppression via BMAL1 destabilization ( Drosophila ortholog of HDR1, called septin interacting protein 3 (sip3), in circadian regulation has not been identified

Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies